Welcome to the MVRL homepage.

We are delighted to announce we will host the 2013 British Association for Cancer Research Meeting on Tumour Microenvironment - Basic science to novel therapies -  from July 3rd-4th 2013, featuring:

Doug Hanahan (Lausanne) Gosse Adema (Nijmegen)  Bronek Pytowski (Imclone) Helge Wiig (Bergen) Jacqueline Shields (Cambridge) Holger Gerhardt (London/Leuven) Francis Balkwill (London) Michael Olson (Glasgow) Gordon Jayson (Manchester)

Kari Alitalo (Helsinki) Elise Kohn (NCI, NIH) Stefan Schulte Merker (Utrecht), Kairbaan Hodivala-Dilke (London) Eyad Elkord (Salford) Claire Lewis (Sheffield) Steve Wedge (Newcastle) Chris Schofield (Oxford) Steven Harper (Bristol)

Principal Investigators

David Bates Professor of Microvascular Biology and Medicine Scientific Director, MVRL, School of Physiology and Pharmacology. email: Dave.Bates@bris.ac.uk

Steve Harper Honorary Professor in Physiology and Pharmacology Clinical Director, MVRL, Consultant Nephrologist, Academic Renal Unit, Southmead Hospital. Email: S.Harper@bris.ac.uk

Dr Andy Salmon MRC Clinician Scientist, Clinical Senior Lecturer/Consultant in Nephrology, (Academic Renal Unit) and Physiology and Pharmacology Andy.Salmon@bristol.ac.uk

Dr Chris Neal Honorary Research Fellow, School of Physiology and Pharmacology Chris.Neal@bris.ac.uk

Dr Sebastian Oltean Research Fellow, School of Physiology and Pharmacology Sebastian.Oltean@bris.ac.uk

Thank you for your interest in the MVRL.

Research Interests

Angiogenesis Our angiogenesis research focuses on: 1. The biology of the anti-angigoenic splice variants of VEGF we disovered in 2002 2. Therapeutic angiogenesis and arteriolargenesis, particularly with respect to the formation of physiologically normal vasculature.	Vascular permeability We are investigating how microvessels control fluid and solute movement from blood to tissue, the role of the endothelial surface layer, the junctional proteins and the endothelial signalling mechanisms,and how this is altered in angiogenesis and in diseases such as pre-eclampsia, Dengue fever and cancer.	Renal microcirculation End stage renal failure often results from damage to the filtering units of the kidney, the glomerulus. We are investigating how the structure and function of the glomerular barrier is controlled by the surrounding cells, the podocytes, as well as the lining cells, the endothelial cells in health and disease.
Ophthalmology Our discovery that VEGF isoforms are altered in eye disease, and the concept that blocking blood vessel growth has led us to develop tools that can modify angiogenesis and prevent cells in the eye from dying. We are developing new drugs to treat Age Related Macular Degeneration, diabetic retinopathy and other eye conditions.	Neuronal protection Vascular growth factors also act on the nervous system both directly by changing blood vessels that supply nerves, and directly by acting on VEGF receptors on neurons. The discovery that VEGFs can protect neurons from cell death has lead us to investigate how this might occur, and its effect on different neuronal types.	Tumour metastasis Many cancers kill due to spread from their point of origin (e.g. skin, breast) to other organs (e.g. brain, lung). We have identified novel moelcular mechanisms by which tumour cells can escape their environment and find their way to lymph nodes and then to distant organs. We are trying to develop inhibitors of these as novel cancer therapies.

Microvascular Biology and Medicine.

Postdoctoral Research Assistants and Associates	Postgraduate Students	Technicians, postgraduate students and Clinical Fellows
Dr Yan Qiu Cancer Research UK Postdoctoral Research Associate, from China Yan.Qiu@bris.ac.uk	Athina Mavrou. Prostate Reseacrh Campaign funded PhD Student. From Cyprus.	Amy Russell.  MRC technician and PhD student. From Scotland
Dr Maryam Hamdollah- Zadeh Wellcome Trust Postdoctoral Research Associate, from Iran	Kai Betteridge MRC funded PhD Student	Megan Stevens.  MRC technician and PhD student
Dr Richard Hulse. Diabetes UK funded Postdoctoral Researcher (Working jointly with Dr Lucy Donaldson).	Nikita Ved. Diabetes UK PhD student (Joint with Professor James Bainbridge, UCL)	Dr Shaney Barratt Wellcome Trust Clinical Training Fellow (working jointly with Dr Ann Millar)
Dr Karen Brakspear. MRC Funded postdoctoral Researcher	Xi Ye. British Heart Foundation PhD Student. (Joint with Dr Amanda Churchill, Ophthalmology)	Sarah Moeschler Cancer Research Technologies Funded Research Technician (working jointly with JP Girard, Unviersity of Toulouse) from Switzerland
Jim Carter. CRT Funded postdoctoral researcher.	Jenny Castle Miller. BBSRC PhD Student (joint with Dr Domingo Tortonese, Anatomy)	Eleanor Star. BBSRC technican and PhD student (from Wales)
Maria Machado. BHF Funded postdoctoral researcher (from Portugal)	Sara Desideri. Kidney Research UK funded PhD student. From Italy	Hanna Zielinska. RBVRT funded Technician.
Mel Gammons. BHF funded postdoctoral researcher	Caroline Phelps. BBSRC funded PhD student (working jointly with Lucy Donaldson and Bridget Lumb)
Dr Nick Beazley-Long SCaRF Postdoctoral researcher

Support

Wellcome Trust	British Heart Foundation	Medical Research Council	Diabetes UK	The Richard Bright VEGF Research Trust,	Cancer Research UK
Skin Cancer Research Fund	National Kidney Research Foundation	Prostate Research Campaign	BBSRC

Fight for Sight	Association for International Cancer Research,	Royal College of Surgeons	The Healing Foundation	Bupa Foundation

Contact Details

Teaching links

Microvascular Lab

 Available positions

We are currently advertising for a technician/PhD student.

Recent publications
Including papers in press

 Details of abstracts and posters presented at recent meetings by members of the lab.

The British Microcirculation Society

The BMS home page, with details of conferences, abstracts, a whole load of microcirc. journals, and a lot more.

Links

The Microcirculation Society

Link to the Microcirculatory Society in the United States

Other Vascular Biology links

Link to the home page of the NAVBO, Physsoc, APS and others

Previous students and postdocs

Georgie Cope is now a postdoc at Harvard University working with Valerie Schumacher and Jordan Kredberg.	Dr Silvia Lanati was awarded her PhD in March 2012 and is now working as a postdoctoral researcher at the University of California, Santa Barbara, with Patrick Daugherty in Chemical Engineering (ex-PhD student).	Dr Kenton Arkill is now working as a postdoctoral research associate in Brimingham.
Dr Leslie Sage was awarded her PhD in October 2011 and worked for Obama's campaign as a data analyst in Ohio. She is now in Washington DC working with the Inaugural committee	Kirsty Symonds is working as a laboratory officer at Truro Hospital.	Robert Muston gained his MSc in 2011. He is retired.
Dr Wei Kang Wu is now working as a postdoc in the Dept of Ophthalmology in Bristol with Prof Andrew Dick. (ex-PhD student).	Vadim Alexeenko has returned to Russia.	Dr Maria Peiris Pages is a postdoc in Michael Lisanti's Laboratory at the Unviersity of Manchester, after doing a postdoc at Weill Cornell Medical School, New York City. (ex-PhD student).
Dr Gopinath Damodaran is now a Barts and London charitable Trust Research Fellow at the Centre for cutaneous research, Barts and The London School of Medicine and Dentistry, Blizard Institute of Cell and Molecular Science, in London.	Dr Elianna Amin is a Postdoctoral Scientist at the Memorial Sloane Kettering Cancer Center in New York, in Michael Kharas' group (ex PhD student)	Dr Coralie Hoareau-Aveilla is a postdoctoral research fellow at the University of Toulouse
Dr Emma Rennel is working as a Senior Scientist for Olink Biosciecne AB in Stockholm	Dr Oliver Stone took a postdoc at the University of California, San Francisco working with Didier Stainer on angiogenesis in zebrafish, and moved recently to the Max Planck Institute at Bad Neuheim (ex PhD student)	Dr Joanne Ferguson is studying Medicine in Bristol (ex-PhD student).
Dr Jeanette Woolard is a Seriously Cool Lecturer in Cardiovascular Pharmacology at the University of Nottingham	Maxine Emmett is now working as a a postdoc with Rowan Pritchard-Jones in Liverpool (ex PhD student)	Dr Cathy Glass went to University of California at Davis for her Postdoctoral Research, gaining a Regenerative Medicine fellowship. (ex PhD student)
Dr Jing Hua is now an Instructor at the Schepens Eye Institute in Boston after completing a fellowship with Reza Dana and postdoc work with Professor Lois E.H. Smith at Harvard Medical School, Children's Hospital.	Mr Darryl Dunn is completing his plastic surgery training in Oxford	Dr Dawid Nowak completed an MSc in Bioscience Enterprise at Cambridge University, and then moved to Cold Spring Harbor Laboratories as a postdoctoral researcher with Lloyd Trotman (ex PhD student)
Mr Alex Varey was a Clinical Research Fellow/RCS Surgical Registrar and Hunterian Professor of Surgery for 2007-8. He is now working as a specialist registrar in plastic surgery in the South West.	Dr Anette Magnussen went to work as a postdoctoral Researcher at University College London Cancer Institute.	Arjun Krishnakur is now undertaking a PhD at the Queen's University,Belfast having completed his MSc with us.
Ms  Liz Waine was a Urology Registrar/Visiting Clinical Research Fellow. She completed her MD and is now working as a Specialist Registrar in Surgical Urology.	Dr Andy Benest took a position as a junior team leader with Hellmut Augustin's laboratory in Heidelberg, Germany, followed by a postdoctoral fellowship at the Leeds Institute for Molecular Medicine Tumour Angiogenesis Signal Transduction and Cancer Group (ex PhD student)	Dr Heather Bevan took a postdoctoral position at the Academic Renal Unit at Southmead Hospital working with Dr Simon Satchell, then moved to a position at the University of the Sunshine Coast in Queensland. (ex PhD student)
Mr Rowan Pritchard- Jones was the 2005-6 Hunterian professor of Surgery and is now Consultant/Senior Lecturer in Liverpool	Dr Olga Konopatskaya is currently working as a postdoctoral research associate with Dr Alastair Poole in Pharmacology in Bristol	Dr Hongwei Cheng is working jointly with Jules Hancox in the CRL and Clive Orchard in the Department of Physiology
Tris Pocock is now a teaching fellow in the School of Biological Sciences at the University of Manchester	Dr Rachel Perrin undertook postdoctoral research at the University of California Davis Medical Center in Sacramento, California, with Prof Sarah Yuan, and is now International Development Officer for the Meningitis Research Foundation (ex PhD student)	Dr Becky Foster took a postdoctoral research associate position in Bristol. She is now a BHF Intermediate Fellowship running her own group at Southmead Hospital. (ex PhD student)
Dr Kavita Joory undertook a medical degree at the University of Birmingham, graduating in 2009 and is now a specialist registrar in the West Midlands (ex PhD student)	Dr Jacqui Shields is now a Associated Research Group Leader at the MRC Cancer Unit in Cambridge. (ex PhD student).	Dr Wenying Wang is currently working as a research scientist for Novobiotech in Beijing (ex PhD student)
Dr Andrew (Tai-Gen) Cui is now Professor of Nephrology at the Institute of Nephrology in Beijing	Cheryl Whittles is working in the Department of Biochemistry	Nicky Hillman (Now Nicky Cook) teaches biology in Leicester

Prof Bates' personal links

Links to pages I think are interesting, including skiing, wine and football links

Department Page

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